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2017 Regeneron STS - Matt Perkins

2017 Regeneron STS

Jan. 4th, 2017.
            For the 2017 Regeneron Science Talent Search (STS), George W. Hewlett High School has 1 student among the elite three hundred high school seniors named scholars (or semifinalists). These students were selected from “1,749 applicants hailing from 527 high schools in 46 states and seven American and international high schools overseas. The scholars were selected on the basis of their exceptional promise as scientists, excellent record of academic achievement and outstanding recommendations from teachers and other scientists.”

The student is Matthew Perkins!!


                                                            Matthew Perkins

Title of Research: Alpha and Beta Adrenergic Agonists Increase Hindrance to Diffusion of 3-kDa Dextran in Mouse Visual Cortex Extracellular Space

Research Summary:

Sleep is believed to play a role in the clearance of potentially harmful substances that accumulate during wakefulness. During sleep, there was a noticeable increase in the volume of the extracellular space (ECS) in the brains of mice. In his research, Matthew Perkins simulated sleep and wake state in the brain tissues of mice by the addition chemicals that mimic the actions of neurotransmitters. His results demonstrated that sleep could affect the diffusion of large molecule through extracellular space of the brain. This data supports the idea that when animals are asleep, potentially toxic substances like beta-amyloid can be cleared at a much faster rate. Matt conducted his research at SUNY Downstate Medical Center under the mentor of Dr. Sabina Hrabetova and completed his project for submission under the guidance of Dr. Terrence Bissoondial in this research class. 

The Next Step:

From the 300 scholars, 40 will be selected as STS Finalists on Jan.24th, 2017. ”Finalists receive an all-expenses-paid trip to Washington, D.C. from March 9-15, where they will compete for more than $1.8 million in awards provided by Regeneron.”

2017 Regeneron STS